Neuronal activity induces CDK5-dependent tau phosphorylation and packaging into exosomes. Selective CDK5 inhibition prevents loading and reduces trans-synaptic tau spreading. Requires development of selective CDK5 inhibitors (not pan-CDK inhibitors like dinaciclib).
Auto-built from this analysis's top knowledge-graph edges.
graph TD
CDK5["CDK5"] -->|regulates| tau_packaging_into_exosom["tau packaging into exosomes"]
p25_CDK5_hyperactivity["p25/CDK5 hyperactivity"] -->|causes| tau_hyperphosphorylation["tau hyperphosphorylation"]
CDK5_1["CDK5"] -->|regulates| memory_consolidation["memory consolidation"]
style CDK5 fill:#4fc3f7,stroke:#333,color:#000
style tau_packaging_into_exosom fill:#4fc3f7,stroke:#333,color:#000
style p25_CDK5_hyperactivity fill:#4fc3f7,stroke:#333,color:#000
style tau_hyperphosphorylation fill:#4fc3f7,stroke:#333,color:#000
style CDK5_1 fill:#4fc3f7,stroke:#333,color:#000
style memory_consolidation fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for CDK5 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for CDK5.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.