Pericyte-to-fibroblast transition contributes to BBB breakdown and impairs glymphatic clearance. Chronic PDGFRβ signaling triggers pericytes to undergo partial endothelial-mesenchymal transition. These transition-state pericytes lose coverage but gain contractile apparatus, compressing capillaries and reducing cerebral blood flow while impairing AQP4 polarisation necessary for glymphatic clearance.
No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for PDGFRΒ yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for PDGFRβ, SNAI2.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.