Microglia-mediated complement activation (C1q, C3) leads to excessive synaptic pruning in AD. Tau pathology sensitizes neurons to complement-mediated attack. Blocking C1q or C3 may prevent synapse loss independent of amyloid/tau pathology, though complement has homeostatic roles in debris clearance and plasticity.
No linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for C1QA.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.